Codonopsis (often misspelled as "Condonopsis"), also known as Codonopsis pilosula or "Dang Shen," is a traditional herb used in Chinese medicine. Its use to support adrenal function or treat "adrenal fatigue" comes primarily from traditional practice rather than scientific validation. In Traditional Chinese Medicine (TCM), Codonopsis is believed to "tonify Qi" (vital energy) and is sometimes used as a milder, more accessible alternative to Panax ginseng. Practitioners may recommend it for symptoms like fatigue, weakness, and poor appetite, which overlap with those attributed to so-called "adrenal fatigue."

However, "adrenal fatigue" is not a formally recognized medical diagnosis, and there is no direct evidence in scientific literature that Codonopsis specifically supports adrenal gland function or treats this condition. There are a few laboratory and animal studies showing Codonopsis may have adaptogenic, anti-inflammatory, or immunomodulating effects, but these are not specific to adrenal health, nor are they robust human trials.

In summary, the use of Codonopsis for "adrenal fatigue" is justified by tradition rather than clear scientific evidence, and the supporting data is limited and indirect.