Evidence supporting the use of: Glycyrrhiza (unspecified)
For the health condition: Adrenal Fatigue

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Glycyrrhiza, most commonly referring to Glycyrrhiza glabra (licorice root), has a long history of traditional use in various systems of medicine, including Traditional Chinese Medicine (TCM) and Ayurveda. In the context of "adrenal fatigue"—a non-medical term used to describe a cluster of symptoms purportedly caused by chronic stress and diminished adrenal function—licorice has been used to "support" the adrenal glands. The rationale is based on glycyrrhizin, a compound in licorice that inhibits the enzyme 11β-hydroxysteroid dehydrogenase, leading to prolonged activity of endogenous cortisol. Historically, licorice was considered to enhance vitality and support stress adaptation, which is why it is sometimes included in herbal formulas for adrenal support.

However, the concept of adrenal fatigue itself is not recognized by mainstream medicine, and there are no robust clinical trials specifically evaluating licorice for this indication. Licorice has been used in cases of adrenal insufficiency (Addison’s disease) in the past to potentiate the effects of corticosteroids, but its use in "adrenal fatigue" is based on tradition rather than scientific consensus. Potential adverse effects, such as hypertension and hypokalemia, are well documented. In summary, while there is traditional use and some mechanistic justification, high-quality scientific evidence for its efficacy in "adrenal fatigue" is lacking.

More about Glycyrrhiza (unspecified)
More about Adrenal Fatigue

Products containing Glycyrrhiza (unspecified)

We currently have no products on Vitabase that contain this ingredient.