Evidence supporting the use of: Schisandrin
For the health condition: Adrenal Fatigue

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Schisandrin, a lignan compound found in the berries of Schisandra chinensis, is traditionally used in Chinese medicine as an adaptogen and tonic, believed to support vitality, liver function, and stress resilience. The concept of “adrenal fatigue” is not recognized in conventional medicine, but in alternative and holistic circles, it describes a non-specific set of symptoms attributed to chronic stress and “under-functioning” adrenal glands. While Schisandra chinensis has centuries of use in traditional medicine for countering fatigue and improving resistance to stress, there is little direct scientific evidence specifically linking schisandrin or Schisandra extracts with measurable improvement in adrenal gland function or the treatment of “adrenal fatigue” as described in alternative health literature.

Some animal and in vitro studies suggest that schisandrin may modulate stress response by affecting levels of cortisol and other stress hormones, and it possesses antioxidant and hepatoprotective properties. However, these studies are preliminary, do not focus on “adrenal fatigue” as a clinical entity, and human trials are limited. Therefore, the use of schisandrin for adrenal fatigue is primarily justified by traditional use, with minimal scientific validation. Most supporting claims are extrapolated from broader research on stress adaptation or are rooted in longstanding herbal practice rather than rigorous clinical evidence specific to the condition.

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