Evidence supporting the use of: Schisandrins
For the health condition: Adrenal Fatigue

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Schisandrins, the active lignans found in the fruit of Schisandra chinensis, have a long history of use in Traditional Chinese Medicine (TCM) as an adaptogen—herbs believed to help the body resist stressors of all kinds, including physical, chemical, or biological. In TCM, Schisandra is used to "preserve qi" and combat fatigue, enhance endurance, and promote vitality. The modern concept of "adrenal fatigue" is not recognized as a medical diagnosis in conventional medicine, but it is commonly described in alternative and integrative health circles as a collection of symptoms related to chronic stress and presumed suboptimal adrenal function.

While there is some laboratory and animal research suggesting that Schisandrins may help modulate the hypothalamic-pituitary-adrenal (HPA) axis and might have anti-fatigue or anti-stress effects, direct scientific evidence for their efficacy in treating "adrenal fatigue" in humans is lacking. Most clinical research focuses on general anti-stress, antioxidant, or hepatoprotective effects, not directly on the adrenal glands. Thus, the use of Schisandrins for this purpose is driven primarily by traditional and historical precedent, rather than robust clinical validation. The evidence supporting its use for "adrenal fatigue" specifically is therefore considered weak, but traditional use is well documented.

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