Whole adrenal glandular supplements are primarily used to support or treat "Adrenal Fatigue" based on traditional naturopathic and alternative medicine practices rather than robust scientific validation. The concept of "Adrenal Fatigue" itself is controversial and not widely accepted in mainstream medicine; most endocrinologists recognize only well-defined adrenal insufficiency disorders such as Addison’s disease, which are diagnosed with specific clinical and laboratory findings. Despite this, proponents in alternative health circles have recommended whole adrenal glandular products for decades, claiming these supplements can "nourish" the adrenal glands and support hormone balance, energy levels, and stress resilience.

Historically, glandular therapy—using animal organ extracts—emerged in the early 20th century, predating the isolation and synthesis of specific hormones. Early practitioners believed that consuming animal glands could help support the equivalent organs in humans. However, contemporary scientific studies evaluating the efficacy of whole adrenal glandular supplements for "Adrenal Fatigue" are lacking. There are no high-quality randomized controlled trials demonstrating benefit, and the physiological basis for oral glandular supplements affecting human adrenal function remains unproven. Regulatory agencies such as the FDA do not recognize "Adrenal Fatigue" as a medical diagnosis, and caution is advised regarding the safety and standardization of glandular products.

In summary, the use of whole adrenal glandular for "Adrenal Fatigue" is rooted in traditional practices and anecdotal reports, with minimal direct scientific evidence to support its use for this condition.