Synopsis

Source of validity: Traditional
Rating (out of 5): 2

The use of "Adrenal" supplements—often containing extracts from animal adrenal glands—has its roots primarily in traditional and naturopathic medicine rather than in robust scientific validation. Historically, such supplements were used in the early 20th century before the synthesis and purification of specific hormones like cortisol. Practitioners believed that consuming glandular extracts could support the corresponding human organ through the concept of "like supports like." This idea persists in certain naturopathic and alternative health circles, where adrenal extracts are promoted for "adrenal fatigue" or to generally support adrenal gland function. However, scientific evidence supporting these uses is sparse and not robust. Most clinical studies on adrenal extracts are outdated, small, or methodologically weak. Regulatory agencies like the FDA have not approved adrenal extracts for any medical use, and there is a lack of high-quality, peer-reviewed research validating their efficacy. Furthermore, the concept of "adrenal fatigue" itself is not recognized by mainstream endocrinology. While there is a traditional basis for the use of adrenal extracts, the strength of evidence is low, and potential risks—such as contamination or unpredictable hormone content—exist. In summary, adrenal supplements are used based on traditional practices, not on solid scientific evidence.

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