Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ammonium glycyrrhizinate is a salt form of glycyrrhizic acid, a major active compound found in licorice root (Glycyrrhiza glabra). Its use to "support the adrenal glands" is primarily based on traditional herbal medicine practices. Licorice root has a long history in traditional systems such as Traditional Chinese Medicine (TCM) and Ayurveda, where it is believed to help with stress, fatigue, and symptoms associated with adrenal insufficiency. The rationale comes from glycyrrhizin’s ability to inhibit the enzyme 11β-hydroxysteroid dehydrogenase type 2, which increases the half-life of cortisol, a key hormone produced by the adrenal cortex. This can lead to mild cortisol-mimetic effects, which some practitioners interpret as “supporting” adrenal function.

However, direct clinical evidence supporting the use of ammonium glycyrrhizinate specifically for adrenal gland support is limited. Most research focuses on its anti-inflammatory and hepatoprotective actions, rather than direct adrenal support. Overuse of glycyrrhizin-containing products can lead to side effects such as hypertension, hypokalemia, and edema due to pseudoaldosteronism, which further complicates its use for adrenal health. In summary, while there is a traditional basis for using licorice derivatives for symptoms associated with adrenal insufficiency or fatigue, robust scientific validation for ammonium glycyrrhizinate as an "adrenal support" supplement is lacking.

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