Mineral blends have traditionally been used in herbal and naturopathic practices to support adrenal gland function, particularly in the context of "adrenal fatigue" or stress-related depletion. The blends often contain minerals such as magnesium, potassium, calcium, and trace elements, which are thought to be depleted during periods of prolonged stress. Historical evidence for their use is largely based on the understanding that the adrenal glands play a role in electrolyte balance and that minerals are required for optimal physiological function, including hormone production and enzymatic processes in the adrenal cortex.

However, while there is historical precedent for using mineral supplementation to support general health and energy, direct scientific evidence specifically validating mineral blends for improving or supporting adrenal gland function is limited. Most studies focus on specific mineral deficiencies (like magnesium or sodium) and their impact on stress response or fatigue, rather than on a blended supplement's effects on adrenal health. The concept of "adrenal fatigue" itself is not widely accepted in mainstream medicine, and clinical trials investigating mineral blends for adrenal support are lacking. Thus, while traditional practice supports their use, scientific validation is weak.