Cistanche deserticola is an herb traditionally used in Chinese medicine, where it is known as "Rou Cong Rong." Historically, it has been valued as a tonic for supporting kidney and reproductive functions, and is classified as a yang tonic in Traditional Chinese Medicine (TCM). In TCM philosophy, the kidneys are considered the foundation of vitality and are closely linked to adrenal function, even though this is not a direct anatomical correlation. As a result, Cistanche is sometimes used in Western herbal blends aimed at supporting the "adrenal glands," but this is based on the traditional TCM concept of kidney support rather than direct evidence of effects on adrenal hormones like cortisol or aldosterone.

Scientific research on Cistanche deserticola has mostly focused on its antioxidant, neuroprotective, anti-fatigue, and immune-modulating properties. Some animal studies suggest anti-fatigue effects, which could be interpreted as adaptogenic or supportive for stress responses, but these studies do not directly examine adrenal gland function or hormone modulation. There is a lack of robust clinical data in humans showing that Cistanche directly supports adrenal health or function.

In summary, the use of Cistanche deserticola for adrenal support is rooted in traditional use and the broader TCM concept of kidney-adrenal connection, with only indirect or limited evidence from scientific studies. Its reputation for supporting adrenal health in Western contexts is extrapolated from its traditional use rather than well-established scientific validation.