Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Cortisol is a glucocorticoid hormone naturally produced by the adrenal cortex and is critical for the proper functioning of the adrenal glands and the body’s response to stress. Its use in medicine is primarily in the form of synthetic analogues (such as hydrocortisone or prednisone) to replace or supplement endogenous cortisol in individuals with adrenal insufficiency (for example, Addison's disease, congenital adrenal hyperplasia, or following bilateral adrenalectomy). There is strong scientific evidence supporting the use of cortisol or its synthetic derivatives in these contexts, as cortisol is essential for maintaining blood pressure, metabolic function, immune modulation, and response to stress.

Clinical guidelines from endocrinology societies recommend glucocorticoid replacement therapy as the standard of care for adrenal insufficiency, and the physiological necessity of cortisol is well established through decades of research and clinical experience. Without sufficient cortisol, patients can develop life-threatening adrenal crises. In summary, the use of cortisol to support adrenal gland function is based on robust scientific evidence and is a mainstay of treatment for documented adrenal insufficiency.

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