Devil's Club (Oplopanax horridus) is a medicinal plant native to the Pacific Northwest of North America, traditionally used by indigenous peoples for a variety of ailments. Its primary historical uses include treatment for rheumatism, diabetes, digestive complaints, and as a general tonic. In the context of supporting the adrenal glands, there is no direct clinical research or pharmacological evidence that links Devil's Club to adrenal function or adrenal health specifically. However, in ethnobotanical literature, Devil's Club has been described as an "adaptogen" by some herbalists, a term used to describe plants believed to help the body resist stressors and support overall resilience, which may include adrenal support by extension.

The traditional use as an adaptogen is largely based on reports from indigenous healers and early ethnobotanical documents, rather than on rigorous scientific studies. Most published studies on Devil's Club focus on its potential anti-diabetic, antimicrobial, or anti-inflammatory properties. There are anecdotal accounts suggesting that it was used for fatigue and to invigorate the body, which are sometimes interpreted as "adrenal support" in modern herbal terminology, but this interpretation is not well-substantiated by controlled studies or phytochemical analyses relevant to adrenal hormone pathways.

In summary, the use of Devil's Club to support the adrenal glands is based on traditional knowledge and some extrapolation by modern herbalists, but lacks direct scientific validation.