Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Honduran Sarsaparilla (Smilax regelii and related species) has a long history of use in traditional herbal medicine, particularly in Central and South America. Its use for supporting the adrenal glands is primarily rooted in tradition rather than in scientific validation. Historically, sarsaparilla has been used as a general tonic, blood purifier, and treatment for various ailments such as skin diseases and rheumatism. Herbalists have sometimes included it in formulas meant to support overall endocrine or hormonal health, which may include references to adrenal support. However, these uses are based largely on empirical and anecdotal evidence rather than direct clinical studies.

There is a lack of robust scientific research directly linking Honduran Sarsaparilla to improved adrenal gland function. While sarsaparilla contains phytochemicals like saponins and phytosterols, which have demonstrated anti-inflammatory and antioxidant properties in laboratory studies, there are no well-conducted human trials showing its efficacy for adrenal support or for treating adrenal insufficiency. As such, its use for this purpose remains traditional, with a moderate to low level of evidence (2/5), mostly based on historical and anecdotal reports rather than modern scientific validation.

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