Indian Nightshade (Solanum indicum or sometimes referring to Solanum nigrum) has a history of use in traditional Ayurvedic and Unani medicine. In these systems, it is used for a wide range of conditions, including as a general tonic and for supporting various organs. Its use for "adrenal gland support" specifically, however, is not commonly documented in traditional texts under that terminology, since the concept of the adrenal glands as understood in modern medicine did not exist in ancient times. However, Indian Nightshade is often classified as a 'rasayana' (rejuvenative) herb in Ayurveda, which implies a general adaptogenic effect and support for energy, vitality, and resilience—qualities that could be interpreted as supporting adrenal function in a modern context.

There is sparse scientific research directly linking Indian Nightshade to adrenal gland health or function. Most available studies focus on its anti-inflammatory, antioxidant, and hepatoprotective properties. The adaptogenic classification is based more on traditional usage and broad effects on body homeostasis rather than on rigorous clinical research specific to the adrenal glands. Thus, while traditional use suggests some potential for supporting bodily resilience (which could theoretically include adrenal health), scientific validation for this specific effect is currently limited.

In summary, the use of Indian Nightshade for adrenal support is justified primarily by tradition, with moderate but not strong evidence, and lacks direct scientific backing for this specific application.