Evidence supporting the use of: Rosarin
For the body system: Adrenal Glands

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Rosarin is a compound found in Rhodiola rosea, a plant traditionally used in Russian and Scandinavian medicine to combat fatigue and support endurance. Modern scientific research has investigated Rhodiola rosea and its constituent compounds, including rosarin, for their adaptogenic properties—meaning their ability to help the body resist physical, chemical, and biological stressors. Several clinical studies have shown that standardized extracts of Rhodiola rosea can reduce fatigue, improve mood, and enhance stress resilience, all of which are functions associated with adrenal gland activity. The mechanism is thought to involve modulation of the hypothalamic-pituitary-adrenal (HPA) axis, which controls stress hormone (cortisol) release. However, while most research examines extracts containing multiple active compounds (rosavin, salidroside, rosarin), there is limited evidence isolating rosarin's specific effects. The overall body of evidence does support the use of Rhodiola rosea for stress adaptation, but direct evidence for rosarin alone is weaker. Thus, while Rhodiola rosea and its compounds are reasonably supported for adrenal support, the evidence is not definitive or solely attributable to rosarin.

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