Siberian ginseng (Eleutherococcus senticosus), often referred to as "eleuthero," is traditionally used in herbal medicine systems, particularly in Russia and China, to support the body's response to stress and enhance stamina. This traditional use is linked to the concept of "adaptogens," substances believed to help the body adapt to physical and mental stressors, which includes supporting adrenal gland function. The adrenal glands are responsible for producing hormones like cortisol and adrenaline that regulate the body’s stress response.

Scientific studies on Siberian ginseng's specific effects on adrenal gland function are limited and generally of low quality. Most available research focuses on its potential to improve general stress resilience, reduce fatigue, and enhance mental performance, rather than directly measuring adrenal hormone output or gland health. Some animal studies suggest possible modulation of stress hormones, but human trials are small and results are inconsistent. Reviews in scientific literature often note the lack of robust, well-designed clinical trials.

In summary, the use of Siberian ginseng to support the adrenal glands is primarily justified by traditional use and the broader adaptogen concept. There is insufficient scientific evidence to conclusively validate these effects in humans, and more rigorous research is needed to clarify its role in adrenal support.