Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Sodium ascorbate is a mineral salt of ascorbic acid (vitamin C) and is sometimes promoted in alternative health circles as beneficial for adrenal gland support. This traditional use is based on the fact that the adrenal glands contain high concentrations of vitamin C and utilize it in the synthesis of stress-related hormones such as cortisol. Historical naturopathic and integrative medicine sources often recommend vitamin C supplementation (including sodium ascorbate) for individuals experiencing stress or adrenal fatigue, theorizing that high demand for cortisol may deplete vitamin C stores in the adrenals.

However, while vitamin C is indeed involved in adrenal physiology, there is limited direct scientific evidence that supplementing with sodium ascorbate specifically has a significant, measurable effect on adrenal function or on conditions like "adrenal fatigue" (a diagnosis not recognized by mainstream medicine). Most human studies focus on general vitamin C supplementation and its effects on immune function or oxidative stress, rather than targeted adrenal support. Animal and in vitro studies do show that vitamin C is necessary for catecholamine and cortisol synthesis, but clinical trials in humans showing benefit for adrenal health are lacking.

In summary, the use of sodium ascorbate to support adrenal glands is rooted in traditional and naturopathic practice, with some physiological rationale but minimal direct clinical evidence. The overall evidence rating for its use in adrenal support is therefore low.

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