Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Triterpenoids are a large class of naturally occurring compounds found in many plants, including licorice (Glycyrrhiza glabra), ginseng (Panax ginseng), and various medicinal mushrooms. Traditionally, extracts containing triterpenoids have been used in herbal medicine systems, such as Traditional Chinese Medicine (TCM) and Ayurveda, to support the adrenal glands and promote vitality. For example, licorice root, which contains glycyrrhizin (a triterpenoid saponin), has historically been used for its purported adaptogenic properties and to help the body manage stress. Similarly, ginseng and some mushrooms like Ganoderma lucidum (reishi) are rich in triterpenoids and are claimed to support adrenal health, energy, and resilience. However, while these traditional uses are well-documented, the scientific evidence specifically linking unspecified triterpenoids to direct support of adrenal gland function is limited and often indirect. Most studies focus on specific triterpenoids or extracts, not on the broad class as a whole, and results are varied. Some animal studies suggest certain triterpenoids may influence stress response hormones, but robust clinical trials in humans are lacking. Therefore, the practice of using triterpenoids to support adrenal gland health is primarily based on historical use rather than strong scientific validation.

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