Evidence supporting the use of: Withanolides
For the body system: Adrenal Glands

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Withanolides are a group of naturally occurring steroidal lactones primarily found in the plant Withania somnifera, commonly known as ashwagandha. Ashwagandha has a long history of use in traditional Ayurvedic medicine, particularly for its adaptogenic properties, which are believed to help the body resist physiological and psychological stress. In recent years, scientific studies have begun to investigate the mechanisms and efficacy of withanolides, especially in relation to stress and adrenal gland function.

Preclinical and clinical research suggests that withanolides may modulate the hypothalamic-pituitary-adrenal (HPA) axis, which governs the body's response to stress. Several randomized controlled trials indicate that ashwagandha root extract, standardized for withanolide content, can reduce cortisol levels—a key hormone produced by the adrenal glands in response to stress—and improve subjective measures of stress and anxiety. For example, a double-blind, placebo-controlled study published in 2012 found that participants taking ashwagandha had significantly reduced serum cortisol levels compared to placebo.

However, while these findings are promising and support the use of withanolides for promoting healthy adrenal function under stress, the evidence is not yet robust. Many studies are limited by small sample sizes, short durations, and variations in extract standardization. Consequently, while there is scientific validation for the adaptogenic effects of withanolides and their potential support for the adrenal system, more large-scale and long-term research is needed to fully substantiate these effects.

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