Evidence supporting the use of: Acetyl L-Tyrosine
For the body system: Adrenal Medulla

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Acetyl L-Tyrosine is a modified form of the amino acid L-tyrosine, which serves as a precursor for the synthesis of catecholamines, including dopamine, norepinephrine, and epinephrine. The adrenal medulla, a part of the adrenal glands, is responsible for producing and secreting epinephrine and norepinephrine. Supplementing with L-tyrosine (and its acetylated variant, acetyl L-tyrosine) is thought to potentially support the function of the adrenal medulla by providing the necessary substrate for catecholamine production, particularly under conditions of acute stress or catecholamine depletion.

Scientific studies have shown that tyrosine supplementation can help maintain cognitive performance and mood during acute stressors such as cold exposure, sleep deprivation, and military training. These effects are attributed to the maintenance of catecholamine levels in the brain rather than direct action on the adrenal medulla. There is some indirect evidence that tyrosine can help replenish norepinephrine and epinephrine stores under stress, but direct clinical evidence linking acetyl L-tyrosine supplementation to improved adrenal medulla function in humans is limited.

Overall, while the theoretical basis for using acetyl L-tyrosine to support catecholamine synthesis exists, the scientific evidence specifically validating its efficacy for adrenal medulla support in humans is weak to moderate, justifying a rating of 2 out of 5.

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