Eleutherococcus gracilistylus, also known as “ci wu jia,” is a plant used in traditional Chinese medicine (TCM). It is closely related to Eleutherococcus senticosus (“Siberian ginseng”), which is more commonly referenced in Western herbalism. In TCM, Eleutherococcus species are historically used as adaptogens—herbs believed to help the body resist stress and support various physiological functions, which may include the adrenal system. However, the direct association with the adrenal medulla is not explicitly documented in classical or modern herbal texts; instead, the focus is generally on “tonifying qi” and enhancing vitality, which are broad concepts not limited to adrenal medullary function.

Scientific studies on Eleutherococcus gracilistylus specifically are limited. Some animal and in vitro studies suggest adaptogenic effects, such as modulation of the hypothalamic-pituitary-adrenal (HPA) axis and possible anti-stress effects, but robust clinical evidence in humans is lacking. There is no direct evidence showing a targeted effect on the adrenal medulla (the part of the adrenal gland responsible for catecholamine production). Overall, the use of this herb to “support the adrenal medulla” is primarily based on traditional adaptogen concepts rather than validated scientific research.

In summary, Eleutherococcus gracilistylus has a tradition of use for general vitality and “adaptation to stress,” but there is little to no direct scientific or historical evidence specifically supporting its use for the adrenal medulla.