Evidence supporting the use of: Genseng (not specified)
For the body system: Adrenal Medulla

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ginseng, particularly Panax ginseng and Panax quinquefolius, has a long history of use in traditional medicine systems such as Traditional Chinese Medicine (TCM) and Korean herbal medicine. It is generally considered an "adaptogen," a substance believed to help the body resist physical, chemical, or biological stressors. In traditional frameworks, ginseng is thought to support overall vitality, energy, and resilience, which are sometimes interpreted as effects on the adrenal glands, including the adrenal medulla, although historical texts do not typically reference the adrenal medulla specifically (since it was not anatomically defined in ancient times). Rather, ginseng's use for “qi” (vital energy) and stress may be retroactively linked to adrenal support in modern interpretations.

Scientifically, ginsenosides (active compounds in ginseng) have been shown in animal and in vitro studies to modulate the hypothalamic-pituitary-adrenal (HPA) axis and to affect levels of stress hormones such as cortisol and adrenaline. However, direct evidence that ginseng specifically supports the adrenal medulla (which is responsible for secreting catecholamines like adrenaline and noradrenaline) in humans is limited. Most studies focus on general anti-fatigue, anti-stress, or cognitive effects. Thus, while traditional use for enhancing stress resilience aligns loosely with adrenal medulla function, high-quality clinical studies directly demonstrating support for the adrenal medulla are lacking.

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