Schizandrol A is a bioactive lignan compound found in the fruit of Schisandra chinensis, a plant commonly used in traditional Chinese medicine (TCM). In TCM, Schisandra is regarded as an adaptogen, believed to help the body resist physical, chemical, and biological stressors. It has been traditionally used to "tonify the Qi" and support vitality, which is sometimes interpreted in modern herbalism as supporting adrenal function, including the adrenal medulla, the part of the adrenal gland responsible for secreting adrenaline and noradrenaline.

However, direct traditional references to Schizandrol A itself for specifically supporting the adrenal medulla are lacking. The association is more indirect, arising from the general adaptogenic reputation of Schisandra and its supposed effects on stress resilience and energy. Scientific studies specifically examining the effects of Schizandrol A on adrenal medulla function in humans are minimal. Some animal and in vitro studies indicate that Schizandrol A may modulate neurotransmitter levels and protect against stress-induced changes, but these do not clearly establish a direct link to adrenal medulla support.

Therefore, the use of Schizandrol A to support the adrenal medulla is primarily justified by tradition, with weak and indirect evidence. There is a notable gap in robust scientific validation for this specific application.