False Unicorn (Chamaelirium luteum) has a longstanding history of use in traditional herbal medicine, particularly among Native American and 19th-century American Eclectic physicians, for various gynecological complaints. Its use for afterbirth pain—discomfort and cramping experienced after childbirth as the uterus contracts back to its normal size—stems from these historical applications. Traditionally, False Unicorn was considered a "uterine tonic," believed to help regulate and tone the uterus, manage menstrual irregularities, and address symptoms associated with childbirth, including afterbirth pain.

Despite its historical use, there is a lack of modern clinical research or robust pharmacological studies directly supporting the efficacy of False Unicorn specifically for afterbirth pain. The available evidence comes almost exclusively from herbal texts, ethnobotanical reports, and anecdotal accounts rather than from controlled scientific studies. No active compounds within False Unicorn have been conclusively shown to relieve uterine pain or promote postpartum recovery in humans. Thus, while the herb’s use for afterbirth pain is rooted in tradition, it is not validated by modern clinical science, and safety concerns (such as potential toxicity at high doses) remain insufficiently studied.

In summary, False Unicorn's use for afterbirth pain is based on traditional herbal practices, and evidence supporting its effectiveness is weak (rated 1/5), relying on historical rather than scientific sources.