Stone Root (Collinsonia canadensis) has a history of use in traditional herbal medicine, particularly among Native American and 19th-century American herbalists. It was commonly used for a variety of ailments, especially those involving the pelvic region, vascular system, and urinary tract. There are scattered historical references to Stone Root being used for conditions associated with childbirth, including afterbirth pain (the cramping discomfort some women experience as the uterus contracts post-delivery). Herbalists believed Stone Root's purported astringent and antispasmodic properties could help tone the uterus and alleviate cramping.

However, modern scientific research on Stone Root is extremely limited, and there are no clinical trials or pharmacological studies that specifically evaluate its efficacy for afterbirth pain or uterine cramping. The evidence for its use in this context is almost entirely anecdotal or based on traditional herbal literature, such as the writings of 19th-century eclectic physicians. Contemporary herbal references may repeat these traditional uses, but they do not cite rigorous evidence. Therefore, while Stone Root has been used traditionally for afterbirth pain, there is little to no scientific validation for this application.