Evidence supporting the use of: Arbutin
For the health condition: Age Spots

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Arbutin is a naturally occurring glycosylated hydroquinone found in various plants, including bearberry. It is commonly used in topical formulations for the treatment of age spots (also known as solar lentigines or liver spots) and other forms of hyperpigmentation. The scientific rationale for its use is based on its ability to inhibit tyrosinase, a key enzyme involved in the synthesis of melanin. Multiple in vitro studies have demonstrated that arbutin effectively reduces melanin production in cultured melanocytes. Additionally, some clinical studies have shown that topical application of arbutin-containing products can lead to a visible reduction in hyperpigmented lesions, including age spots, over several weeks to months of use.

Arbutin is considered safer than hydroquinone, a related compound with well-documented depigmenting effects but more significant side effects, partly because arbutin releases hydroquinone slowly. Systematic reviews and clinical guidelines recognize arbutin as one of several effective agents for treating hyperpigmentation, although results can vary based on concentration, formulation, and individual skin type. While the evidence base is not as large as for some prescription treatments, the available studies support its efficacy and safety profile for mild to moderate hyperpigmentation, including age spots.

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Products containing Arbutin

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