Azelaic acid is scientifically validated for the treatment of age spots (also known as hyperpigmentation or lentigines). Numerous clinical studies have demonstrated that azelaic acid, typically at concentrations of 15-20%, inhibits tyrosinase, a key enzyme involved in melanin synthesis. By reducing melanin production, it helps to fade hyperpigmented lesions, including age spots. Azelaic acid is also an antioxidant and has anti-inflammatory properties, which further support its role in improving skin tone and texture.

Research has shown that azelaic acid is effective in treating various forms of hyperpigmentation, such as melasma and post-inflammatory hyperpigmentation, both of which share pathogenic mechanisms with age spots. In randomized clinical trials, azelaic acid demonstrated a significant reduction in the size and intensity of pigmented lesions over 12-24 weeks of use, with a safety profile favorable compared to other agents like hydroquinone.

While azelaic acid is not traditionally used in folk medicine for age spots, its use in dermatology is well-established and backed by scientific literature and dermatological guidelines. Therefore, it is considered a scientifically validated, evidence-based ingredient for supporting the treatment of age spots.