The use of vitamin E (specifically tocopheryl acetate) to support or treat age spots—also known as liver spots or solar lentigines—is primarily rooted in tradition and popular skincare practice rather than robust scientific evidence. Historically, vitamin E has been touted for its antioxidant properties and its perceived ability to improve skin health. Many over-the-counter creams and serums marketed for hyperpigmentation or age spots include vitamin E, often due to its reputation for skin repair and protection against oxidative stress caused by UV exposure.

However, clinical studies directly examining the efficacy of topical vitamin E (tocopheryl acetate) for fading age spots are limited and show minimal to no significant benefit. Some studies have investigated vitamin E in combination with other antioxidants or ingredients, with mixed results. The mechanism by which vitamin E could theoretically help—by neutralizing free radicals and potentially reducing melanin formation—is plausible, but not well-established in clinical settings for age spots specifically.

In summary, while the use of vitamin E for age spots is common and has a long-standing tradition in skincare, scientific validation for its effectiveness in this specific context is weak or lacking. Most recommendations are based on its general skin health benefits rather than targeted evidence for treating hyperpigmentation or age spots.