Evidence supporting the use of: 8-Prenylnaringenin
For the health condition: Aging (prevention)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
8-Prenylnaringenin (8-PN) is a prenylated flavonoid found primarily in hops (Humulus lupulus) and is recognized as one of the most potent phytoestrogens. Scientific research on 8-PN has focused largely on its estrogenic activity, with several studies examining its potential benefits for menopausal symptoms, bone health, and hormone-related conditions. Regarding aging and its prevention, the evidence is limited but growing.
Experimental research suggests that 8-PN may exert anti-aging effects by modulating oxidative stress and influencing estrogen receptor pathways. Some animal and in vitro studies indicate that 8-PN can upregulate antioxidant enzymes and reduce markers of cellular damage associated with aging. Additionally, its estrogenic effects may contribute to the maintenance of skin elasticity and bone density, both of which decline with age. However, the majority of clinical research to date has focused on menopausal symptom relief rather than direct anti-aging outcomes.
There is currently a lack of large-scale, high-quality human trials specifically evaluating 8-PN for aging prevention or longevity. Most supportive evidence is preclinical or extrapolated from its estrogenic and antioxidant properties. As such, while there is a scientific rationale and some preliminary evidence, the strength and quality of the data are modest, and further research is needed to establish clear benefits for aging prevention.
Other ingredients used for Aging (prevention)
7-hydroxymatairesinol (HMR)7-Keto-DHEA
acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
amino acids
anthocyanins
apple
apricot
ascorbyl palmitate
ashwagandha
astaxanthin
astragalus
beta-carotene
brussel sprouts
carrot
catalase
cauliflower
coenzyme Q10 (CoQ10)
collagen
cryptoxanthin
turmeric
curcumin
DHEA (dehydroepiandrosterone)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
ginkgo biloba
green tea
greens blend (proprietary)
l-carnosine
lutein
magnesium
matcha
melatonin
mixed carotenoids
nicotinamide riboside
omega-3 fatty acids
polypeptide complex (proprietary)
protein
quercetin
resveratrol
rhodiola
sardines
selenium
silicon
soybean
trans-pterostilbene
almond fruit
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
watermelon
zinc
β-nicotinamide mononucleotide (NMN)
cistanche
dodder
royal jelly
polyphenols
anemarrhena asphodeloides
yerba mate
goji berry
algae
AMP-activated protein kinase (AMPK)
soy isoflavones
ashitaba
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
8-Prenylnaringenin
Antler
Apigenin
Aronia melanocarpa
Antrodia camphorata
Anserine
Avocado
Alpha Hydroxy Acids
Allantoin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Algal protein
anthocyanosides
Argan nut oil
Abalone
Brassica
Bioflavonoids
Bird's nest
Carnosine
Curcuminoid
Cruciferous
Cycloastragenol
Chinese Ligustrum berry
Carotene (unspecified)
Dunaliella salina
Dismutase
DHEA
Dunaliella
Epidermal Growth Factor
epicatechin
Ellagic Acid
Ergothioneine
Flavonoids
fibroblast growth factor
Other health conditions supported by 8-Prenylnaringenin
Aging (prevention)Estrogen (low)
Hot Flashes
Menopause
Osteoporosis
Vaginal Dryness