Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Akkermansia muciniphila is a beneficial gut bacterium that has attracted considerable scientific interest for its potential role in healthy aging. Animal studies have demonstrated that A. muciniphila abundance is associated with improved metabolic health, reduced inflammation, and enhanced gut barrier function—all factors implicated in age-related decline. In particular, research in mice models suggests that supplementation with A. muciniphila or its pasteurized form can improve glucose tolerance, decrease fat mass, and increase markers of gut integrity, which may translate to increased healthspan. Some studies have observed that levels of this bacterium tend to decrease with age, and that restoring its levels might counteract certain aspects of age-associated physiological deterioration. However, direct evidence in humans is limited. Small pilot trials have shown that supplementation is safe and may have favorable effects on metabolic markers, but robust clinical trials directly assessing its impact on aging or longevity are lacking. There is currently no traditional use of A. muciniphila for aging; its exploration is recent and based on mechanistic and preclinical studies. Thus, while its use is justified by emerging scientific rationale, the strength of evidence supporting its role in aging prevention is still preliminary (rated 2/5), pending larger human studies to validate these promising findings.

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Products containing Akkermansia muciniphila

Metagenics Akkermansia Co.™ Healthy Weight with Glucose Control
Metagenics UltraFlora Triplebiotic