Evidence supporting the use of: Alpha-GPC
For the health condition: Aging (prevention)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Alpha-GPC (L-Alpha glycerylphosphorylcholine) is a choline-containing phospholipid that has gained attention primarily for its potential cognitive-enhancing and neuroprotective properties. Scientific interest in Alpha-GPC focuses on its ability to increase acetylcholine levels in the brain, a neurotransmitter important for memory and learning. Several clinical studies and animal models have explored Alpha-GPC’s efficacy in age-related cognitive decline, Alzheimer’s disease, and other dementias. Some trials indicate modest improvements in cognitive performance among elderly subjects with mild to moderate dementia or cognitive impairment. However, these studies generally involve cognitive function rather than aging itself as a biological process.
There is currently no robust scientific evidence that Alpha-GPC directly prevents or slows the aging process as a whole. Its use in “anti-aging” supplements is largely extrapolated from its effects on cognitive symptoms associated with aging, rather than aging prevention itself. Regulatory agencies do not recognize Alpha-GPC as an anti-aging therapy. The evidence base for its role in cognitive aging is moderate (hence the rating of 2/5), but for direct aging prevention, it is weak or absent. In summary, Alpha-GPC has some scientific backing for use in age-related cognitive decline, but not as an intervention for aging prevention in general.
Other ingredients used for Aging (prevention)
7-hydroxymatairesinol (HMR)7-Keto-DHEA
acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
amino acids
anthocyanins
apple
apricot
ascorbyl palmitate
ashwagandha
astaxanthin
astragalus
beta-carotene
brussel sprouts
carrot
catalase
cauliflower
coenzyme Q10 (CoQ10)
collagen
cryptoxanthin
turmeric
curcumin
DHEA (dehydroepiandrosterone)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
ginkgo biloba
green tea
greens blend (proprietary)
l-carnosine
lutein
magnesium
matcha
melatonin
mixed carotenoids
nicotinamide riboside
omega-3 fatty acids
polypeptide complex (proprietary)
protein
quercetin
resveratrol
rhodiola
sardines
selenium
silicon
soybean
trans-pterostilbene
almond fruit
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
watermelon
zinc
β-nicotinamide mononucleotide (NMN)
cistanche
dodder
royal jelly
polyphenols
anemarrhena asphodeloides
yerba mate
goji berry
algae
AMP-activated protein kinase (AMPK)
soy isoflavones
ashitaba
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
8-Prenylnaringenin
Antler
Apigenin
Aronia melanocarpa
Antrodia camphorata
Anserine
Avocado
Alpha Hydroxy Acids
Allantoin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Algal protein
anthocyanosides
Argan nut oil
Abalone
Brassica
Bioflavonoids
Bird's nest
Carnosine
Curcuminoid
Cruciferous
Cycloastragenol
Chinese Ligustrum berry
Carotene (unspecified)
Dunaliella salina
Dismutase
DHEA
Dunaliella
Epidermal Growth Factor
epicatechin
Ellagic Acid
Ergothioneine
Flavonoids
fibroblast growth factor
Other health conditions supported by Alpha-GPC
Aging (prevention)Alzheimer's Disease
Athletic and Exercise Aids
Body Building
Circulation (to the brain)
Concentration (poor)
Dementia
Fatigue
Memory and Brain Function
Parkinson's Disease