Evidence supporting the use of: Alpha-Ketoglutarate
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-Ketoglutarate (AKG) is a key intermediate in the Krebs (citric acid) cycle, playing a vital role in cellular energy production and amino acid metabolism. Interest in AKG for aging prevention stems from animal and cellular studies suggesting that it may influence lifespan and age-related processes. A notable 2020 study in the journal Cell Metabolism demonstrated that calcium AKG supplementation extended median lifespan and healthspan in mice, apparently by reducing inflammation and age-related signaling pathways (link). Additional research has indicated that AKG levels decline with age in humans and that supplementation may help offset age-associated physiological decline.

However, robust clinical evidence in humans is lacking. Most supportive data come from preclinical animal studies or in vitro research. There are only preliminary human trials, often with small sample sizes or focused on other endpoints (e.g., muscle metabolism, not direct aging markers). Thus, while scientific rationale exists and animal data are promising, current evidence for AKG’s effectiveness in preventing or treating aging in humans is limited, warranting a moderate-low evidence rating.

In summary, the use of AKG for aging prevention is justified by early scientific research, primarily in animal models, but lacks strong human clinical validation at this time.

More about Alpha-Ketoglutarate
More about Aging (prevention)

Other ingredients used for Aging (prevention)

7-hydroxymatairesinol (HMR)
7-Keto-DHEA
acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
amino acids
anthocyanins
apple
apricot
ascorbyl palmitate
ashwagandha
astaxanthin
astragalus
beta-carotene
brussel sprouts
carrot
catalase
cauliflower
coenzyme Q10 (CoQ10)
collagen
cryptoxanthin
turmeric
curcumin
DHEA (dehydroepiandrosterone)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
ginkgo biloba
green tea
greens blend (proprietary)
l-carnosine
lutein
magnesium
matcha
melatonin
mixed carotenoids
nicotinamide riboside
omega-3 fatty acids
polypeptide complex (proprietary)
protein
quercetin
resveratrol
rhodiola
sardines
selenium
silicon
soybean
trans-pterostilbene
almond fruit
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
watermelon
zinc
β-nicotinamide mononucleotide (NMN)
cistanche
dodder
royal jelly
polyphenols
anemarrhena asphodeloides
yerba mate
goji berry
algae
AMP-activated protein kinase (AMPK)
soy isoflavones
ashitaba
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
8-Prenylnaringenin
Antler
Apigenin
Aronia melanocarpa
Antrodia camphorata
Anserine
Avocado
Alpha Hydroxy Acids
Allantoin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Algal protein
anthocyanosides
Argan nut oil
Abalone
Brassica
Bioflavonoids
Bird's nest
Carnosine
Curcuminoid
Cruciferous
Cycloastragenol
Chinese Ligustrum berry
Carotene (unspecified)
Dunaliella salina
Dismutase
DHEA
Dunaliella
Epidermal Growth Factor
epicatechin
Ellagic Acid
Ergothioneine
Flavonoids
fibroblast growth factor

Products containing Alpha-Ketoglutarate

We currently have no products on Vitabase that contain this ingredient.