Evidence supporting the use of: Anemarrhena asphodeloides
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Anemarrhena asphodeloides is a perennial herb traditionally used in Chinese medicine, where it is known as "zhi mu" (知母). In the historical context of Traditional Chinese Medicine (TCM), Anemarrhena asphodeloides is commonly included in formulas to "clear heat," "nourish yin," and "moisten dryness." These effects are believed to help address symptoms associated with aging, such as dryness, fatigue, and cognitive decline, which are interpreted as manifestations of "yin deficiency." Specifically, zhi mu is an ingredient in the well-known TCM formula Zhi Bai Di Huang Wan, which is often prescribed for signs of aging or menopause-related symptoms.

Modern scientific studies on Anemarrhena asphodeloides have identified several active compounds, such as mangiferin and saponins, that possess antioxidant and anti-inflammatory properties. These mechanisms are broadly linked to the aging process, as oxidative stress and chronic inflammation contribute to cellular aging. However, direct human clinical trials investigating its effectiveness in preventing or reversing aging are lacking. Most available evidence is from laboratory and animal studies showing potential anti-aging effects at the molecular level (e.g., reduced oxidative damage, improved cognitive markers in animal models).

In summary, the use of Anemarrhena asphodeloides for aging prevention is rooted primarily in traditional practice, with some preliminary scientific rationale but limited clinical validation. Therefore, its use for this purpose is best described as "traditional" with moderate supporting evidence from laboratory studies, but not yet substantiated by rigorous human trials.

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7-hydroxymatairesinol (HMR)
7-Keto-DHEA
acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
amino acids
anthocyanins
apple
apricot
ascorbyl palmitate
ashwagandha
astaxanthin
astragalus
beta-carotene
brussel sprouts
carrot
catalase
cauliflower
coenzyme Q10 (CoQ10)
collagen
cryptoxanthin
turmeric
curcumin
DHEA (dehydroepiandrosterone)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
ginkgo biloba
green tea
greens blend (proprietary)
l-carnosine
lutein
magnesium
matcha
melatonin
mixed carotenoids
nicotinamide riboside
omega-3 fatty acids
polypeptide complex (proprietary)
protein
quercetin
resveratrol
rhodiola
sardines
selenium
silicon
soybean
trans-pterostilbene
almond fruit
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
watermelon
zinc
β-nicotinamide mononucleotide (NMN)
cistanche
dodder
royal jelly
polyphenols
anemarrhena asphodeloides
yerba mate
goji berry
algae
AMP-activated protein kinase (AMPK)
soy isoflavones
ashitaba
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
8-Prenylnaringenin
Antler
Apigenin
Aronia melanocarpa
Antrodia camphorata
Anserine
Avocado
Alpha Hydroxy Acids
Allantoin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Algal protein
anthocyanosides
Argan nut oil
Abalone
Brassica
Bioflavonoids
Bird's nest
Carnosine
Curcuminoid
Cruciferous
Cycloastragenol
Chinese Ligustrum berry
Carotene (unspecified)
Dunaliella salina
Dismutase
DHEA
Dunaliella
Epidermal Growth Factor
epicatechin
Ellagic Acid
Ergothioneine
Flavonoids
Fo-Ti
fibroblast growth factor

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