Evidence supporting the use of: Curcumin
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Curcumin, the active polyphenolic compound found in turmeric (Curcuma longa), has garnered significant scientific interest for its potential role in aging prevention. Preclinical studies suggest that curcumin exhibits strong antioxidant, anti-inflammatory, and neuroprotective properties. These effects are relevant in the context of aging, as oxidative stress and chronic low-grade inflammation (“inflammaging”) are recognized contributors to cellular aging and age-related diseases. In animal models, curcumin has been shown to modulate signaling pathways involved in longevity, such as the sirtuin, AMPK, and mTOR pathways. It also appears to reduce markers of oxidative damage and improve cognitive and cardiovascular function in aged animals. Human evidence is growing, but remains limited and somewhat inconsistent. Some small-scale clinical trials have reported improvements in markers of oxidative stress, inflammation, and even cognitive function in older adults taking curcumin supplements. However, other studies have failed to find significant benefits, possibly due to issues with curcumin’s low bioavailability and differences in formulations used. Overall, while there is promising scientific evidence from laboratory and animal studies and some early human trials, more large-scale, long-term clinical research is needed to confirm curcumin’s efficacy in aging prevention. Thus, the use of curcumin for this purpose is justified by a moderate level of scientific evidence.

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Other ingredients used for Aging (prevention)

7-hydroxymatairesinol (HMR)
7-Keto-DHEA
acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
amino acids
anthocyanins
apple
apricot
ascorbyl palmitate
ashwagandha
astaxanthin
astragalus
beta-carotene
brussel sprouts
carrot
catalase
cauliflower
coenzyme Q10 (CoQ10)
collagen
cryptoxanthin
turmeric
curcumin
DHEA (dehydroepiandrosterone)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
ginkgo biloba
green tea
greens blend (proprietary)
l-carnosine
lutein
magnesium
matcha
melatonin
mixed carotenoids
nicotinamide riboside
omega-3 fatty acids
polypeptide complex (proprietary)
protein
quercetin
resveratrol
rhodiola
sardines
selenium
silicon
soybean
trans-pterostilbene
almond fruit
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
watermelon
zinc
β-nicotinamide mononucleotide (NMN)
cistanche
dodder
royal jelly
polyphenols
anemarrhena asphodeloides
yerba mate
goji berry
algae
AMP-activated protein kinase (AMPK)
soy isoflavones
ashitaba
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
8-Prenylnaringenin
Antler
Apigenin
Aronia melanocarpa
Antrodia camphorata
Anserine
Avocado
Alpha Hydroxy Acids
Allantoin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Algal protein
anthocyanosides
Argan nut oil
Abalone
Brassica
Bioflavonoids
Bird's nest
Carnosine
Curcuminoid
Cruciferous
Cycloastragenol
Chinese Ligustrum berry
Carotene (unspecified)
Dunaliella salina
Dismutase
DHEA
Dunaliella
Epidermal Growth Factor
epicatechin
Ellagic Acid
Ergothioneine
Flavonoids
fibroblast growth factor