Evidence supporting the use of: Cycloastragenol
For the health condition: Aging (prevention)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Cycloastragenol is a molecule derived from Astragalus membranaceus, a traditional Chinese medicinal herb. Its use for aging prevention is primarily supported by recent scientific interest rather than long-standing traditional use. Cycloastragenol has been investigated for its potential to activate telomerase, the enzyme responsible for maintaining telomere length. Telomeres are protective DNA sequences at the ends of chromosomes that shorten with each cell division, and critically short telomeres are associated with cellular senescence and aging.
Preclinical studies, mainly in cell cultures and animal models, have shown that cycloastragenol can stimulate telomerase activity, leading to increased telomere length and potentially delayed senescence in some cell types. A few small human studies and pilot trials (often involving dietary supplements such as TA-65) have reported modest improvements in immune function and some biomarkers associated with aging, but these studies are generally limited by small sample sizes, lack of robust controls, and short durations.
There is currently no high-quality, long-term clinical evidence demonstrating that cycloastragenol supplementation leads to increased lifespan, prevention of age-related diseases, or substantial improvements in human healthspan. The available evidence justifies cautious optimism but does not yet support strong claims for its effectiveness in aging prevention. More rigorous and large-scale clinical trials are needed to establish its safety and efficacy in humans.
Other ingredients used for Aging (prevention)
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid7-hydroxymatairesinol (HMR)
7-Keto-DHEA
8-Prenylnaringenin
Abalone
Acai berry
Acetyl L-carnitine
Akkermansia muciniphila
Algae
algal oil
Algal protein
Allantoin
Almond fruit
Alpha hydroxy acids
Alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
anemarrhena asphodeloides
anserine
anthocyanidins
anthocyanins
anthocyanosides
antler
Antrodia camphorata
apigenin
apple
apricot
argan nut oil
Aronia melanocarpa
ascorbyl palmitate
ashitaba
ashwagandha
astaxanthin
astragaloside
astragalus
avocado
beta-carotene
bioflavonoids
bird\'s nest
Brassica
Brussel sprouts
Carnosine
carotene (unspecified)
carrot
catalase
cauliflower
Chinese Ligustrum berry
cistanche
coenzyme Q10 (CoQ10)
collagen
cruciferous
cryptoxanthin
curcumin
Curcuminoid
cycloastragenol
DHEA
DHEA (dehydroepiandrosterone)
dismutase
dodder
Dunaliella
Dunaliella salina
ellagic acid
epicatechin
Epidermal Growth Factor
epigallocatechin gallate (EGCG)
ergothioneine
fibroblast growth factor
fisetin
flavonoids
flaxseed
fo-ti
fucoxanthin
Gac
Gerovital H3
ginkgo biloba
Ginsenosides
Glabridin
goji berry
green tea
greens blend (proprietary)
Haematococcus pluvialis
hazelnut
HMB hydroxymethylbutyrate
hydroxymethylbutyrate
icariin
L-carnosine
lutein
Lycium
magnesium
Matcha
Melatonin
mixed carotenoids
nicotinamide riboside
Oligomeric proanthocyanidins
omega-3 fatty acids
oolong tea
Peptides
Phytoene
Phytofluene
polypeptide complex (proprietary)
polyphenols
protein
pyrroloquinoline quinone
quercetin
resveratrol
Rhodiola
royal jelly
Salidroside
selenium
Shilajit
silicon
soy isoflavones
soybean
Squalene
Trans-pterostilbene
Tremella
Triterpenes
turmeric
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
Watermelon
Xanthophyll
Yerba mate
Zinc
β-nicotinamide mononucleotide (NMN)