Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fisetin is a flavonoid compound found in various fruits and vegetables, including strawberries, apples, and onions. Its use in aging prevention is supported primarily by scientific, rather than traditional, evidence. Preclinical studies, particularly in animal models, have demonstrated that fisetin acts as a senolytic agent—meaning it selectively induces death of senescent cells, which accumulate with age and contribute to age-related tissue dysfunction and inflammation. Notably, a 2018 study published in EBioMedicine by Yousefzadeh et al. found that fisetin administration in aged mice reduced senescent cell burden, improved tissue function, and extended lifespan. Subsequent research has supported these findings, indicating fisetin’s potential to modulate pathways involved in oxidative stress, inflammation, and cellular aging.

Despite these promising findings in animal models, robust clinical evidence in humans is still limited. A few small-scale human trials are underway, but as of now, they have not conclusively demonstrated anti-aging benefits. Therefore, while the scientific rationale is compelling and fisetin is gaining attention as a potential agent for promoting healthy aging, the overall evidence remains preliminary. It is important to note that fisetin has not been traditionally used for aging prevention in herbal or folk medicine. More high-quality human studies are needed to confirm its efficacy and safety for this purpose.

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