Evidence supporting the use of: L-carnosine
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-carnosine is a naturally occurring dipeptide composed of beta-alanine and histidine, found in high concentrations in muscle and brain tissues. Its use in aging prevention is primarily supported by scientific rationale, though the evidence is still preliminary and mostly derived from laboratory and animal studies rather than large-scale clinical trials in humans. L-carnosine possesses antioxidant properties, allowing it to scavenge reactive oxygen species and chelate metal ions, which are processes believed to contribute to cellular aging. In vitro studies have demonstrated that L-carnosine can delay cellular senescence and reduce the formation of advanced glycation end products (AGEs), which are implicated in age-related tissue damage and chronic diseases.

Animal research has shown that supplementation with L-carnosine may extend lifespan and improve markers of healthspan, such as cognitive function and physical endurance, in rodents. However, evidence in humans is limited. Some small studies have suggested potential benefits for cognitive function and skin appearance, but robust clinical data supporting its use specifically for aging prevention are lacking. Overall, while the mechanistic basis for L-carnosine’s anti-aging effects is scientifically plausible, the current level of evidence in humans is insufficient for strong clinical recommendations, placing it at a moderate level of scientific support (rated 2 out of 5).

More about l-carnosine
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Other ingredients used for Aging (prevention)

7-hydroxymatairesinol (HMR)
7-Keto-DHEA
acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
amino acids
anthocyanins
apple
apricot
ascorbyl palmitate
ashwagandha
astaxanthin
astragalus
beta-carotene
brussel sprouts
carrot
catalase
cauliflower
coenzyme Q10 (CoQ10)
collagen
cryptoxanthin
turmeric
curcumin
DHEA (dehydroepiandrosterone)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
ginkgo biloba
green tea
greens blend (proprietary)
l-carnosine
lutein
magnesium
matcha
melatonin
mixed carotenoids
nicotinamide riboside
omega-3 fatty acids
polypeptide complex (proprietary)
protein
quercetin
resveratrol
rhodiola
sardines
selenium
silicon
soybean
trans-pterostilbene
almond fruit
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
watermelon
zinc
β-nicotinamide mononucleotide (NMN)
cistanche
dodder
royal jelly
polyphenols
anemarrhena asphodeloides
yerba mate
goji berry
algae
AMP-activated protein kinase (AMPK)
soy isoflavones
ashitaba
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
8-Prenylnaringenin
Antler
Apigenin
Aronia melanocarpa
Antrodia camphorata
Anserine
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Alpha Hydroxy Acids
Allantoin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Algal protein
anthocyanosides
Argan nut oil
Abalone
Brassica
Bioflavonoids
Bird's nest
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Curcuminoid
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Cycloastragenol
Chinese Ligustrum berry
Carotene (unspecified)
Dunaliella salina
Dismutase
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Epidermal Growth Factor
epicatechin
Ellagic Acid
Ergothioneine
Flavonoids
fibroblast growth factor