Evidence supporting the use of: Lignan
For the health condition: Aging (prevention)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Lignans are a group of polyphenolic compounds found in plants, particularly in seeds (especially flaxseed), whole grains, and vegetables. Their use for aging prevention is supported by some scientific evidence, although the evidence is not robust. Lignans are phytoestrogens, meaning they can weakly mimic or modulate the action of estrogen in the body. Several observational studies and some small clinical trials suggest that lignan consumption may be associated with reduced risks of chronic diseases related to aging, such as cardiovascular disease, certain cancers (notably breast and prostate cancer), and possibly cognitive decline. These effects are thought to be due to lignans' antioxidant, anti-inflammatory, and hormone-modulating properties.
However, most of the research is preliminary, often involving animal models or in vitro studies rather than large-scale human trials. While some meta-analyses and reviews suggest potential benefits, they also note significant heterogeneity in study design, lignan sources, and measured outcomes. There is little direct evidence that lignan supplementation alone can prevent or reverse aging, but their inclusion as part of a plant-rich diet appears to contribute to healthy aging by supporting cardiovascular, hormonal, and possibly cognitive health. Overall, lignans show promise, but current evidence is moderate and not sufficient for strong clinical recommendations.
Other ingredients used for Aging (prevention)
7-hydroxymatairesinol (HMR)7-Keto-DHEA
acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
amino acids
anthocyanins
apple
apricot
ascorbyl palmitate
ashwagandha
astaxanthin
astragalus
beta-carotene
brussel sprouts
carrot
catalase
cauliflower
coenzyme Q10 (CoQ10)
collagen
cryptoxanthin
turmeric
curcumin
DHEA (dehydroepiandrosterone)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
ginkgo biloba
green tea
greens blend (proprietary)
l-carnosine
lutein
magnesium
matcha
melatonin
mixed carotenoids
nicotinamide riboside
omega-3 fatty acids
polypeptide complex (proprietary)
protein
quercetin
resveratrol
rhodiola
sardines
selenium
silicon
soybean
trans-pterostilbene
almond fruit
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
watermelon
zinc
β-nicotinamide mononucleotide (NMN)
cistanche
dodder
royal jelly
polyphenols
anemarrhena asphodeloides
yerba mate
goji berry
algae
AMP-activated protein kinase (AMPK)
soy isoflavones
ashitaba
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
8-Prenylnaringenin
Antler
Apigenin
Aronia melanocarpa
Antrodia camphorata
Anserine
Avocado
Alpha Hydroxy Acids
Allantoin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Algal protein
anthocyanosides
Argan nut oil
Abalone
Brassica
Bioflavonoids
Bird's nest
Carnosine
Curcuminoid
Cruciferous
Cycloastragenol
Chinese Ligustrum berry
Carotene (unspecified)
Dunaliella salina
Dismutase
DHEA
Dunaliella
Epidermal Growth Factor
epicatechin
Ellagic Acid
Ergothioneine
Flavonoids
fibroblast growth factor
Other health conditions supported by Lignan
Aging (prevention)Breast Lumps
Cancer (natural therapy for)
Cancer (prevention)
Cardiovascular Disease
Cholesterol (high)
Inflammation
Menopause
Triglycerides (high)