Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Royal jelly is a secretion produced by honeybees and has long been used in traditional medicine, particularly in Asia, for its purported health benefits, including anti-aging effects. Scientifically, royal jelly contains various bioactive compounds such as proteins (notably royalactin), amino acids, fatty acids, vitamins, and polyphenols, which are thought to contribute to its antioxidant and anti-inflammatory properties. Some in vitro and animal studies suggest that royal jelly may modulate oxidative stress and enhance collagen production, both of which are linked to aging processes. For example, research in rodents has shown royal jelly supplementation can improve cognitive function, skin elasticity, and lifespan, likely through mechanisms involving antioxidative pathways and hormonal modulation (e.g., estrogenic activity). However, human clinical evidence is limited and generally of low quality. A few small-scale studies in humans have reported modest improvements in skin hydration, reduction in wrinkles, or lipid profile changes, but findings are often inconsistent, and sample sizes are small. The lack of large, well-controlled clinical trials makes it difficult to draw firm conclusions about its efficacy for aging prevention in humans. Overall, while there is a plausible scientific rationale and some preliminary evidence, the use of royal jelly for aging prevention is not strongly supported by robust clinical research at this time, warranting a low to moderate evidence rating.

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