Evidence supporting the use of: Agmatine
For the health condition: Alcoholism

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Agmatine is a naturally occurring compound derived from the amino acid arginine. In the context of alcoholism, preclinical studies—primarily in animal models—have explored agmatine's potential benefits in reducing alcohol consumption and mitigating withdrawal symptoms. The rationale stems from agmatine's role as a neuromodulator and its interactions with multiple neurotransmitter systems, including the modulation of NMDA and imidazoline receptors, as well as the inhibition of nitric oxide synthase. These mechanisms are implicated in the neurobiology of addiction and withdrawal. Some rodent studies have demonstrated that agmatine administration can attenuate alcohol intake, decrease alcohol-induced neurotoxicity, and ameliorate some withdrawal symptoms. For example, research published in the early 2000s indicated that agmatine reduced ethanol consumption and withdrawal severity in rats. However, these findings have not yet been robustly translated into human clinical trials. There are no large-scale, well-controlled studies in humans confirming agmatine's efficacy for treating alcoholism, and its use for this purpose is not supported by major clinical guidelines or medical organizations. In summary, while there is a scientific rationale and limited preclinical evidence suggesting agmatine may have beneficial effects related to alcoholism, the evidence is preliminary and lacks validation in human populations. Its use in this context should be considered experimental, and further research is needed to establish safety and efficacy in humans.

More about Agmatine
More about Alcoholism

Products containing Agmatine

We currently have no products on Vitabase that contain this ingredient.