Evidence supporting the use of: Dihydromyricetin
For the health condition: Alcoholism

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Dihydromyricetin (DHM), also known as ampelopsin, is a flavonoid compound found in the Japanese raisin tree (Hovenia dulcis). Its use to support or treat alcoholism stems primarily from preclinical scientific research, rather than traditional medicine or clinical trials. In animal studies, particularly a 2012 study published in The Journal of Neuroscience, DHM was shown to counteract acute alcohol intoxication and reduce alcohol consumption in rodents. DHM appears to modulate GABAA receptors in the brain, reversing the alcohol-induced potentiation of these inhibitory receptors, which may explain its effects on reducing intoxication and withdrawal symptoms.

However, despite promising results in animal models, there is a lack of robust clinical evidence in humans. A 2022 review in Frontiers in Pharmacology noted that while DHM shows potential as a therapeutic agent for alcohol use disorder, there are currently no large-scale, well-controlled human trials confirming its efficacy or safety for this indication. Thus, the scientific evidence is preliminary (rated 2/5), mostly based on preclinical data, and further research is required before DHM can be considered a validated treatment for alcoholism in humans.

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Other health conditions supported by Dihydromyricetin

Alcoholism
Fatty Liver Disease
Hangover
Inflammation
Liver Detoxification

Products containing Dihydromyricetin

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