Evidence supporting the use of: Vitamin B1 (thiamin disulfide)
For the health condition: Alcoholism

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Vitamin B1 (thiamin) is scientifically validated for use in the support and treatment of alcoholism, particularly to prevent or treat Wernicke-Korsakoff syndrome—a serious neurological disorder caused by thiamin deficiency that is common in individuals with chronic alcohol use disorder. Chronic alcohol consumption impairs thiamin absorption, storage, and utilization, leading to deficiency. Thiamin is an essential coenzyme in carbohydrate metabolism and neural function. Deficiency can manifest as confusion, ataxia, and memory disturbances, progressing to irreversible brain damage if untreated.

Clinical guidelines universally recommend thiamin supplementation for individuals with alcohol dependence, especially before administering glucose, as glucose metabolism in the absence of adequate thiamin can precipitate acute Wernicke’s encephalopathy. Numerous studies and systematic reviews support the efficacy of thiamin supplementation in both the prevention and acute management of this condition. Parenteral (intravenous or intramuscular) administration is often preferred in acute settings due to poor gastrointestinal absorption in affected individuals.

Leading authorities such as the World Health Organization (WHO), National Institute on Alcohol Abuse and Alcoholism (NIAAA), and various clinical practice guidelines emphasize the critical role of thiamin in managing and preventing neurological complications associated with alcoholism. Thus, the use of thiamin in this context is supported by high-quality clinical evidence and is standard of care in medical practice.

More about Vitamin B1 (thiamin disulfide)
More about Alcoholism

Other health conditions supported by Vitamin B1 (thiamin disulfide)

Alcoholism
Diabetes
Fatigue
Peripheral Neuropathy
Wasting

Products containing Vitamin B1 (thiamin disulfide)

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