Evidence supporting the use of: Vitamin B1 (thiamin pyrophosphate)
For the health condition: Alcoholism
Synopsis
Source of validity: Scientific
Rating (out of 5): 5
Vitamin B1, also known as thiamine (active form: thiamin pyrophosphate), is scientifically validated for use in supporting and treating alcoholism, especially to prevent or manage Wernicke-Korsakoff syndrome—a severe neurological disorder caused by thiamine deficiency. Chronic alcohol consumption impairs thiamine absorption in the gastrointestinal tract, reduces hepatic storage, and increases its requirement, making alcoholics particularly susceptible to deficiency. Numerous studies and clinical guidelines recommend thiamine supplementation in people with alcohol use disorder, especially those presenting with confusion, ataxia, or oculomotor dysfunction (the classic triad of Wernicke encephalopathy).
Thiamine administration can rapidly reverse early symptoms of deficiency and is crucial to prevent progression to Korsakoff psychosis, a potentially irreversible condition characterized by profound memory impairment. The scientific evidence is robust, supported by both observational and interventional studies, as well as consensus guidelines from organizations such as the World Health Organization and the American Society of Addiction Medicine. Parenteral (intravenous or intramuscular) thiamine is often preferred in acute settings to ensure bioavailability. As such, thiamine (vitamin B1) is a standard and evidence-based component of medical management for individuals with alcoholism at risk for, or presenting with, thiamine deficiency-related complications.
More about Vitamin B1 (thiamin pyrophosphate)
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ornithine L-aspartic acid
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Other health conditions supported by Vitamin B1 (thiamin pyrophosphate)
AlcoholismCongestive Heart Failure
Diabetes
Fatigue
Heart (weakness)
Peripheral Neuropathy