Evidence supporting the use of: Vitamin B6 (Mixed)
For the health condition: Alcoholism

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) is used to support individuals with alcoholism primarily due to scientific evidence highlighting the frequent occurrence of vitamin B6 deficiency in people with chronic alcohol use disorder. Chronic alcohol consumption impairs the absorption and metabolism of various B vitamins, including B6, leading to deficiencies that can contribute to neurological symptoms such as peripheral neuropathy, confusion, and irritability. Supplementation with vitamin B6 is often recommended as part of the broader management of nutritional deficiencies in alcohol-dependent patients to prevent and treat these complications. However, there is limited evidence that vitamin B6 supplementation alone is effective in treating alcoholism itself or preventing relapse; its primary role is supportive, addressing secondary effects of alcohol misuse rather than the addiction per se.

Clinical guidelines, such as those from the World Health Organization and various addiction medicine associations, include vitamin B6 supplementation (often alongside other B vitamins like thiamine and folic acid) as part of the standard care for individuals undergoing alcohol withdrawal or recovery. However, robust randomized controlled trials evaluating B6 alone for direct treatment of alcoholism are lacking. Therefore, while its use is scientifically justified for correcting deficiency states and associated symptoms, the quality of evidence supporting its use for treating alcoholism as a primary condition is moderate at best.

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