Evidence supporting the use of: Vitamin B6 (pyridoxal 5-phosphate)
For the health condition: Alcoholism

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6, specifically in its active form pyridoxal 5-phosphate, has been used as part of nutritional support for individuals with alcoholism primarily due to the high prevalence of B-vitamin deficiencies in this population. Chronic alcohol consumption interferes with the absorption, metabolism, and utilization of several nutrients, including vitamin B6. Deficiency in vitamin B6 can contribute to neurological and psychiatric symptoms, which may overlap with or exacerbate symptoms of alcohol withdrawal or chronic alcohol use. Several studies have documented low plasma levels of vitamin B6 in people with alcohol use disorder, and clinical guidelines for alcohol withdrawal management often recommend supplementation with B vitamins (including B1, B6, and B12) to reduce the risk of complications such as Wernicke-Korsakoff syndrome and to address general nutritional deficits. However, while supplementation is standard in supportive care, there is little evidence that vitamin B6 alone directly treats the underlying addiction or withdrawal symptoms; instead, its use is justified for correcting deficiency and preventing associated complications. The scientific evidence for its use in alcoholism is therefore supportive for deficiency prevention and neurological protection, rather than as a primary treatment for alcoholism itself. The evidence rating is moderate (2 out of 5), as clinical use is based on known deficiency risk and prevention of complications, but not on evidence for direct anti-alcohol effects.

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