Evidence supporting the use of: Ancylostoma brasiliense
For the health condition: Allergies (food)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ancylostoma brasiliense, a species of hookworm, has been explored in scientific research as a potential therapeutic agent for immune-mediated conditions, including allergies such as food allergies. This interest is rooted in the "hygiene hypothesis," which suggests that decreased exposure to helminths and other pathogens in developed countries has led to an increase in allergic and autoimmune diseases. Experimental studies, primarily in animal models, have shown that infection with A. brasiliense or administration of its extracts can modulate the host's immune response, shifting it away from the Th2-type immune reaction that underlies many allergic conditions. Some early-phase human trials using related hookworm species (like Necator americanus) have demonstrated altered immune profiles and, in some cases, reduced allergic symptoms. However, direct clinical evidence for the use of A. brasiliense specifically in treating food allergies in humans is limited. Most data come from preclinical studies, with a few small-scale or pilot human studies using closely related species. While the mechanistic rationale is supported by immunological research, robust clinical trials are lacking, and concerns about safety and practicality remain. Thus, the evidence supporting the use of A. brasiliense for food allergies is preliminary and warrants further investigation before it can be recommended in mainstream clinical practice.

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