Evidence supporting the use of: Diamine oxidase
For the health condition: Allergies (food)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Diamine oxidase (DAO) is an enzyme responsible for breaking down histamine, particularly in the digestive tract. The rationale for its oral supplementation is based on the idea that some individuals experience symptoms similar to food allergies due to histamine intolerance, a condition in which the body cannot effectively degrade ingested histamine. This is distinct from true IgE-mediated food allergies, which are immune reactions, not related to histamine breakdown per se. Some small studies and case reports suggest that DAO supplementation may help reduce symptoms such as headaches, flushing, hives, and gastrointestinal distress in people with histamine intolerance. However, evidence for its use in true food allergies is lacking. The available studies are mostly limited in size, scope, and quality, and no robust, placebo-controlled clinical trials have demonstrated its efficacy for food allergies. Major allergy and immunology guidelines do not recommend DAO as a treatment for food allergies. In summary, while there is a scientific rationale and some preliminary data for DAO in histamine intolerance, there is minimal scientific support for its use in treating or supporting food allergies specifically.

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Other health conditions supported by diamine oxidase

Allergies (food)

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