Evidence supporting the use of: Fructooligosaccharides (FOS)
For the health condition: Allergies (food)

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fructooligosaccharides (FOS) are prebiotic fibers that promote the growth of beneficial gut bacteria, such as Bifidobacteria and Lactobacilli. There is a growing body of scientific interest in the relationship between the gut microbiome and allergic diseases, including food allergies. Some preclinical and small clinical studies suggest that FOS supplementation may modulate immune responses and improve gut barrier function, potentially reducing allergic sensitization and inflammation.

Animal studies have shown that FOS can reduce allergic responses by promoting regulatory T cells and anti-inflammatory cytokines. In humans, a limited number of studies—primarily in infants and children—suggest that prebiotic supplementation might reduce the risk of developing atopic dermatitis and possibly food allergies, especially when given early in life. However, results are not yet consistent or robust enough to recommend FOS as a primary treatment for food allergies. Most guidelines still focus on avoidance and immunotherapy rather than prebiotic supplementation for established food allergies.

In summary, while there is a plausible scientific rationale and preliminary evidence supporting the use of FOS in modulating allergic responses, especially in prevention, the clinical evidence for its effectiveness in treating established food allergies is limited and inconclusive. More high-quality, large-scale human studies are needed to establish clear recommendations.

More about fructooligosaccharides (FOS)
More about Allergies (food)