Evidence supporting the use of: Acinetobacter lwoffii
For the health condition: Allergies (respiratory)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Acinetobacter lwoffii has been investigated in recent years for its possible role in modulating immune responses related to allergic (especially respiratory) conditions. The interest is primarily based on epidemiological and experimental studies supporting the “hygiene hypothesis”—the idea that early-life exposure to certain environmental microbes can protect against the development of allergies and asthma. Notably, research has identified A. lwoffii as a common environmental bacterium found in rural and farming environments, which are associated with lower rates of allergic diseases in children.

A key study by Conrad et al. (2017, Nature Medicine) demonstrated that mice exposed to A. lwoffii F78 developed protection against allergic airway inflammation, likely via induction of regulatory immune responses (such as increased Treg cells and anti-inflammatory cytokines). Moreover, epidemiological evidence suggests that children growing up on farms, with higher exposure to A. lwoffii and related bacteria, have reduced rates of asthma and hay fever compared to their urban counterparts.

However, while these findings are promising, direct clinical use of A. lwoffii as a therapeutic probiotic for allergic respiratory diseases in humans is still at an early stage, with most evidence from animal models and population studies. There have been no large-scale, well-controlled human trials confirming its efficacy or safety for allergy treatment. Therefore, the evidence merits a moderate rating (3/5), indicating scientific support but not yet clinical validation.

More about Acinetobacter lwoffii
More about Allergies (respiratory)

Other health conditions supported by Acinetobacter lwoffii

Allergies (respiratory)
Inflammation

Products containing Acinetobacter lwoffii

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