Evidence supporting the use of: Adrenergic amines
For the health condition: Allergies (respiratory)

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Adrenergic amines (unspecified, but typically including agents like epinephrine and phenylephrine) have a well-established scientific basis for use in the management of respiratory allergies, particularly those involving acute symptoms such as nasal congestion or severe allergic reactions (anaphylaxis). These compounds function as sympathomimetics, stimulating adrenergic receptors (primarily alpha and beta receptors), which leads to vasoconstriction, reduced mucosal edema, and bronchodilation.

For example, phenylephrine and similar agents are commonly included in over-the-counter decongestants to relieve nasal congestion associated with allergic rhinitis. Their efficacy in reducing nasal airway resistance and improving airflow is supported by multiple clinical trials, though some agents (like oral phenylephrine) have faced questions about their clinical effectiveness in some studies. In emergency medicine, epinephrine is the first-line treatment for anaphylaxis, a severe and potentially life-threatening allergic reaction, due to its ability to counteract bronchospasm, airway edema, and hypotension.

Guidelines from organizations such as the American Academy of Allergy, Asthma & Immunology recognize the role of adrenergic amines in the acute treatment of severe allergic reactions. Their use for milder, chronic respiratory allergic symptoms (such as seasonal allergic rhinitis) is typically limited to short-term relief, as long-term use can lead to tolerance and side effects (e.g., rebound congestion with nasal sprays).

In summary, adrenergic amines are scientifically validated for acute allergic respiratory symptoms, with strong evidence supporting their use for emergency anaphylaxis and moderate evidence for short-term relief of allergic rhinitis symptoms.

More about Adrenergic amines
More about Allergies (respiratory)

Products containing Adrenergic amines

We currently have no products on Vitabase that contain this ingredient.