Evidence supporting the use of: Ancylostoma brasiliense
For the health condition: Allergies (respiratory)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ancylostoma brasiliense, a species of hookworm, has been investigated in recent years as part of the broader field of helminth therapy, which explores the use of parasitic worms to modulate immune responses in allergic diseases such as asthma and allergic rhinitis. The rationale is based on the "hygiene hypothesis," which suggests that lack of exposure to certain microbes and parasites in developed countries may contribute to the rising prevalence of autoimmune and allergic conditions. Experimental infections with related hookworm species (notably Necator americanus and Ancylostoma duodenale) in human volunteers have shown some potential to reduce respiratory allergy symptoms and modulate immune responses toward a less inflammatory profile, likely through the induction of regulatory T-cells and changes in cytokine production.

However, direct clinical studies using Ancylostoma brasiliense in humans are extremely limited, with most evidence coming from animal models or extrapolation from other hookworm species. Some animal studies have demonstrated that infection with A. brasiliense can modulate airway inflammation and immune responses in mouse models of asthma, supporting its potential as an immunomodulatory agent. Nevertheless, there are significant safety concerns, as hookworm infection can cause anemia and other complications. Therefore, while there is a growing body of preclinical and early clinical research supporting the general concept of helminth therapy for allergies, the specific use of Ancylostoma brasiliense is supported by moderate scientific evidence (rated 3/5), and further research is needed to establish its efficacy and safety in humans.

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